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KMID : 0390119950350020177
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Journal of Pusan Medical College
1995 Volume.35 No. 2 p.177 ~ p.184
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Serum Levels of Cytokines in Patients with Lymphoma
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Abstract
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A soluble form of interleukin 2 receptor(sIL-2R) is released from activated T cells. Soluble CD8(sCD8) is released from activated suppressor/cytotoxic T cells, reflecting activation of the suppressor/cytotoxic T cell population. We measured the
serum
levels of some cytokines including sIL-2R, sCD8 and TNF-a at diagnosis(29 cases), during emission (8 cases) and in recurrence(11 cases) of malignant lymphoma(NHL) and adult healthy subjects(30 cases) to determine the clinical usefulness of
determination
of these parameters using sandwich enzyme immunoassay . Sera were kept at -20℃in triple aliquots untilheasurement.
In malignant lymphoma patients, the serum levels of sIL-2R were significantly higher than that of normal controls and were significant increase ar an advanced stage. The serum levels of sIL-2R declined to control range in patients achieving
remission.
The patients with relapse and had markedly elevated sIL-2R levels. The serum sIL-2R levels correlated with the degree of tumor burden. The serum levels of sCD8 were significantly higher in higher at recurrence than remission of NHL. Very high
values
were observed in patients with bulky disease(score 4) but there was no correlation between the sCD8 levels and the degree of tumor burden. The serum levels of TNF-a were not different between patient with NHL and normal controls but were higher
at
an
advance stage and in recurrence of NHL than normal controls.
This study indicates that the serum levels of sIL-2R and sCD8 can serve as a reliable indicator of disease status and activity and may used to assess the response to therapy and prognosis in patients with malignant lymphoma.
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KEYWORD
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